Purine Biosynthesis. Big in Cell Division, Even Bigger in Nitrogen Assimilation

Purine biosynthesis. Big in cell division, even bigger in nitrogen assimilation.

Synthesis of the purine ring is a central metabolic function of all cells. The products, AMP and GMP, provide purine bases for DNA and RNA, as well as for a number of essential coenzymes (NAD, NADP, FAD, and coenzyme A) and signaling molecules (e.g. cAMP; Fig. 1). ATP serves as the energy source for many chemical reactions. In addition, in plants, the nucleotides are the precursors for purine a...

THE EFFECTS OF COPPER ON CYTOCHROMES BIOSYNTHESIS, CELL DIVISION IWD MUTAGENESIS IN PARACOCCUS DENITRIFICANS

Factor VIIa gets even bigger.

Thromb Haemost 2008; 99: 653–654 Since its introduction onto the market in 1996, recombinant factor VIIa (rFVIIa: NovoSeven®; Niastase®; produced by Novo Nordisk, Baegsvaerd, Denmark) has become an increasingly important therapeutic option for physicians caring for haemophilia patients with inhibitors. Both because of its short terminal half-life of approximately three hours (1, 2), and the way...

Chromosomal Diseases in Humans (1): Cell Division

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Bigger uncertainties and the Big

We use Bayesian hierarchical models and recent results from the theory of minimax confidence interval estimation to study the effect of prior information in a cosmological inverse problem. We consider the effect of prior information on uncertainty estimates of a linear functional Lx of an infinite-dimensional model x, given noisy observations y = Kx+x. The model represents the cosmic microwave ...